Round each mealtime insulin dose up to the nearest 4 units, then convert unit-per-unit to the Afrezza dose (available in 4-unit and 8-unit cartridges).Insulin aspart ( NovoLog, Fiasp), insulin glulisine ( Apidra), or insulin lispro ( Humalog, Admelog, Lyumjev) to mealtime insulin inhalation powder ( Afrezza ) See Comparison of Insulins ( US) ( Canada) for specifics of meal timing.Insulin aspart ( NovoLog , NovoRapid , Trurapi , Fiasp, Kirsty ), insulin glulisine ( Apidra), or insulin lispro ( Humalog, Admelog, Lyumjev) to insulin aspart ( NovoLog , NovoRapid , Trurapi, Fiasp, Kirsty ), insulin glulisine ( Apidra), or insulin lispro ( Humalog, Admelog, Lyumjev) 3 See Comparison of Insulins ( US) ( Canada) for specifics of meal timing. Rapid-acting insulin analogs have a faster onset of action and a shorter duration of action than human regular insulin.Insulin aspart ( NovoLog , NovoRapid, Trurapi , Fiasp, Kirsty ), insulin glulisine ( Apidra), or insulin lispro ( Humalog, Admelog, Lyumjev) to regular human insulin ( Humulin R , Novolin R , Novolin ge Toronto , Myxredlin , Hypurin Regular ) Round each mealtime insulin dose up to the nearest 4 units, then convert unit-per-unit to the Afrezza dose (available in 4-unit and 8-unit cartridges).

Regular human insulin ( Humulin R , Novolin R ) to mealtime insulin inhalation powder ( Afrezza ) 3 See Comparison of Insulins ( US) ( Canada)for specifics of meal timing. Regular human insulin ( Humulin R , Novolin R , Novolin ge Toronto, Myxredlin, Hypurin Regular ) to rapid-acting insulin analog (insulin aspart, insulin glulisine, insulin lispro ) If converting from Tresiba >80 units/day, divide U-100 insulin twice daily.Give once daily, or divide Levemir twice daily.Insulin degludec ( Tresiba) to NPH, insulin detemir ( Levemir), insulin glargine U-100 ( Lantus, Basaglar, Semglee, Rezvoglar ), or insulin glargine U-300 ( Toujeo) Do not increase the Tresiba dose more often than every 3 to 4 days.Convert total daily dose unit-per-unit and give once daily, or reduce dose by 20% (for patients with type 1 diabetes, twice-daily basal insulin, or pediatrics ) and give once daily.NPH, insulin detemir ( Levemir), insulin glargine U-100 ( Lantus, Basaglar, Semglee, Rezvoglar ), or insulin glargine U-300 ( Toujeo) to insulin degludec ( Tresiba) Insulin glargine U-300 ( Toujeo) to insulin glargine U-100 ( Lantus, Basaglar, Semglee, Rezvoglar ) or insulin detemir ( Levemir) 1,10 If divided twice daily, a higher daily insulin detemir dose may be needed. Give insulin detemir once daily, or divide twice daily.Insulin glargine U-100 ( Lantus, Basaglar, Semglee, Rezvoglar ) to insulin detemir ( Levemir) 13,14 Do not increase the Toujeo dose more often than every It may take ≥5 days to see the maximum effect of the selected dose of Toujeo.Expect that a higher daily dose (about 10% to 18%) of Toujeo will be needed to maintain control.Convert unit-per-unit and give once daily.

Insulin glargine U-100 ( Lantus, Basaglar, Semglee, Rezvoglar ) to insulin glargine U-300 ( Toujeo)

Do not mix insulin glargine with other insulins.

13,14 Do not increase the Toujeo dose more often than every

Levemir twice daily: reduce total daily dose by 20% and give Toujeo once daily.

Levemir once daily: convert unit-per-unit and give Toujeo once daily.

Insulin detemir ( Levemir) to insulin glargine U-300 ( Toujeo) Insulin detemir ( Levemir) to insulin glargine U-100 ( Lantus, Basaglar, Semglee, Rezvoglar ) Insulin glargine U-100 ( Lantus) to/from insulin glargine U-100 ( Basaglar, Semglee, Rezvoglar )

Insulin glargine U-100 : convert unit-per-unit, 3 or reduce dose by 20%.

Insulin glargine U-100 ( Lantus, Basaglar, Semglee, Rezvoglar ) to NPH

Give NPH twice daily (e.g., 50:50 or 2/3 in AM and 1/3 before dinner or at bedtime).

Convert unit-per-unit, 3 or reduce dose by 20%.

13,14 Do not increase the Toujeo dose more often than every

NPH twice daily: reduce total daily dose by 20% and give insulin glargine once daily.

NPH once daily: convert unit-per-unit to U-100 insulin glargine and give once daily.

NPH to insulin glargine U-100 ( Lantus, Basaglar, Semglee, Rezvoglar )

Do not mix insulin detemir with other insulins.

Some patients may require more insulin detemir than NPH.

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